An administrator may want to protect machines with de-duplication active, without creating a conflict between de-duplication, snapshot, or shadow copy applications and Zerto Virtual Replication.

Replication of VMs with active de-duplication is supported with Zerto Virtual Replication.  As de-duplication efforts (i.e. Symantec De-Duplication) take place at the guest OS level, Zerto Virtual Replication is not affected.
 
NOTE: ZVR will not be able to generate application-consistent checkpoints, for example with the ZVR VSS Agent, while a backup/snapshot task is running within the guest OS.